OpenEvidence Organic Growth Opportunities

This play generates thousands of point-of-care answer pages structured around the PICO (Patient, Intervention, Comparison, Outcome) framework to provide immediate clinical guidance. By answering specific, high-intent questions with evidence-backed citations, openevidence.com can capture the 'clinical moment' traffic currently dominated by incumbents like UpToDate.

Example Keywords

• 'when to start SGLT2 inhibitor in HFpEF'
• 'duration of dual antiplatelet therapy after drug eluting stent'
• 'anticoagulation for subsegmental PE'
• 'first-line treatment for H. pylori after clarithromycin failure'

Rationale

Clinicians frequently search for specific intervention guidance during patient encounters. Providing structured, citation-first answers allows openevidence.com to leverage its existing medical information platform status to capture high-intent long-tail queries that the homepage currently does not reach.

Topical Authority

With an Authority Score of 45 and 1,613 referring domains, the site has the foundational trust to rank for complex medical queries, especially when content is supported by its existing partnerships with NEJM and JAMA Network.

Internal Data Sources

Use anonymized in-product query logs to identify high-frequency clinician questions, internal citation layers for evidence mapping, and partner metadata from specialty society guidelines.

Estimated Number of Pages

25,000+ (Covering major specialties, conditions, and intervention questions)

This strategy creates a massive library of drug monograph 'slice pages' focused on specific clinical scenarios such as renal impairment, hepatic failure, and pregnancy. These pages provide structured dosing tables and monitoring requirements that are essential for safe prescribing at the point of care.

Example Keywords

• 'apixaban dosing in renal impairment'
• 'vancomycin dosing AUC calculation protocol'
• 'metformin when to stop eGFR'
• 'Paxlovid drug interactions with statins'

Rationale

Dosing adjustments are among the most frequent and critical searches performed by clinicians. By creating dedicated pages for these scenarios, openevidence.com can bridge the massive keyword gap (95x) between itself and UpToDate.

Topical Authority

The domain's focus on 'Clinical Answers for Clinical Moments' and its existing HIPAA-compliant infrastructure provides the necessary professional credibility to host sensitive medication management data.

Internal Data Sources

Leverage internal medication knowledge objects, FDA labeling summaries, and safety/compliance documentation to ensure differentiated and accurate outputs.

Estimated Number of Pages

40,000+ (Covering top-prescribed drugs across various physiological and procedural scenarios)

This play develops comprehensive 'Approach to' pages that guide clinicians from a chief complaint to a differential diagnosis and initial workup. Each page includes red flags, diagnostic buckets, and next-step logic stratified by patient demographics.

Example Keywords

• 'differential diagnosis of syncope in older adult'
• 'workup for unintentional weight loss'
• 'approach to acute back pain with fever'
• 'evaluation of hematuria in women'

Rationale

Symptom-based searches represent a broad entry point for clinicians early in the diagnostic process. These pages create a dense internal linking structure that can funnel users from general symptoms into the core OpenEvidence product.

Topical Authority

The site's existing organic reach (162k+ visits) despite a limited page count suggests strong latent authority that can be activated by expanding into specialty-specific diagnostic clusters.

Internal Data Sources

Utilize internal specialty taxonomies, anonymized symptom-based query data, and 'ask follow-up' chains to create unique, workflow-aligned content.

Estimated Number of Pages

15,000+ (Covering symptoms across age, sex, and clinical setting modifiers)

This strategy focuses on the interpretation of abnormal lab results and incidental imaging findings, providing clinicians with structured evaluation algorithms. By targeting specific patterns and thresholds, openevidence.com can capture highly specific, long-tail search volume.

Example Keywords

• 'elevated alkaline phosphatase workup'
• 'incidental pulmonary nodule follow-up recommendations'
• 'low anion gap causes'
• 'elevated troponin without MI differential'

Rationale

Lab and imaging interpretations are programmatic SEO sweet spots due to their structured nature and high search frequency. This play helps close the keyword coverage gap by targeting thousands of specific test-result combinations.

Topical Authority

As a leading medical information platform, openevidence.com is naturally positioned to host evidence-based interpretation guidelines that reference major society standards like the ACR or KDIGO.

Internal Data Sources

Use the internal evidence/citation graph, lab-term frequency analytics, and existing 'TL;DR' research entries to provide unique context for the LLM.

Estimated Number of Pages

8,000+ (Covering common and rare lab abnormalities and imaging incidentalomas)

This play generates workflow-ready artifacts such as EHR dotphrases, note templates, and admission order sets for specific conditions. These pages serve as high-utility tools that drive clinician adoption and enterprise-level interest.

Example Keywords

• 'sepsis order set'
• 'asthma exacerbation discharge instructions template'
• 'CHF admission orders'
• 'Epic dotphrase for diabetes follow-up'

Rationale

Clinicians search for templates to improve efficiency and ensure compliance with quality measures. Providing these as static, indexable pages creates a 'product-led SEO' bridge that demonstrates the platform's immediate value.

Topical Authority

The presence of a Trust Center, BAA policies, and HIPAA-compliance announcements on the domain builds the necessary institutional trust for workflow-related content.

Internal Data Sources

Incorporate internal template libraries, clinician advisory inputs, and specialty society guideline metadata to ensure templates are 'best-practice' aligned.

Estimated Number of Pages

2,000+ (Covering major specialties, encounter types, and hospital protocols)

Improvements Summary

Expand four company/trust pages (About + three announcements) from thin posts into intent-matching, first-party answer pages for brand verification queries. Add clear above-the-fold answers, richer sectioning (5–8 H2s + FAQs), author/reviewer proof, and structured data to win page-1 visibility for HIPAA, NEJM, funding/valuation, and “what is OpenEvidence” searches.

Improvements Details

Rewrite H1/title/meta to directly match query intent and add question-led H2 sections plus FAQ blocks targeting terms like "is open evidence hipaa compliant," "open evidence nejm," "openevidence funding," and "what is openevidence." Convert the HIPAA announcement into a compliance landing page with PHI handling, security practices, BAA/retention FAQs, and enterprise/clinician CTAs; add relationship clarification and non-endorsement FAQ on the NEJM page; add public proof and independence FAQs on the funding page; rebuild /about as the canonical product definition with how-it-works steps, review process, and careers links. Create supporting hubs (/trust-center or /security, /press, optional /partnerships/nejm, /careers) and add stronger internal links from homepage + a persistent “Trust/Company” nav; add schema (Organization, NewsArticle/PressRelease, FAQPage, BreadcrumbList, JobPosting).

Improvements Rationale

These pages target high-intent “brand + qualifier” queries where Google often favors authoritative first-party sources, but current pages map to only 1–4 keywords and lack depth vs. competitors. Expanding topical coverage, adding verifiable citations, and tightening internal linking should raise rankings and CTR (including FAQ rich results) while improving conversions on high-CPC trust queries like HIPAA compliance.